CORTICAL DEFICITSIN SCHIZOPHRENIAFrom Genes to FunctionPatricio O’DonnellUniversity of Maryland, Baltimore, MD, USA

Comentario:

Contents:

1. Schizophrenia Genes: Searching for Common Features, Functions,

and Mechanisms……………………………………………………………………………………….1

Paul J. Harrison

2. Towards a Molecular Classification of Illness: Effects

of Schizophrenia Susceptibility Loci on Clinical Symptoms

and Cognitive Function …………………………………………………………………………..17

Anil K. Malhotra, Pamela DeRosse and Katherine E. Burdick

3. Homer: A Genetic Factor in Schizophrenia?……………………………………………29

Karen K. Szumlinski and Todd E. Kippin

4. Neuregulin-erbB Signaling and the Pathogenesis of Schizophrenia…………..73

Christine Roy and Gabriel Corfas

5. Nicotinic Cholinergic Cortical Dysfunction in Schizophrenia …………………..97

Jason R. Tregellas and Robert Freedman

6. A Role for Glutamate Receptors, Transporters, and Interacting

Proteins in Cortical Dysfunction in Schizophrenia …………………………………113

Deborah Bauer, Robert E. McCullumsmith and James H. Meador-

Woodruff

Preface …………………………………………………………………………………………………………xi

Foreword …………………………………………………………………………………………………..xiii

List of Contributors …………………………………………………………………………………….vii

vi Contents

7. Cortical Circuit Dysfunction in the NMDA Receptor Hypofunction

Model for the Psychosis of Schizophrenia ………………………………………………149

Robert Greene

8. Alterations in Hippocampal Function in Schizophrenia: its Genetic

Associations and Systems Implications…………………………………………………..157

Subroto Ghose and Carol A. Tamminga

9. Identifying Novel Target Genes in Psychotic Disorder Network

Association Analyses……………………………………………………………………………..191

Francine M. Benes, Benjamin Lim, David Matzilevich and John Walsh

10. Alterations in Cortical GABA Neurotransmission in Schizophrenia:

Causes and Consequences ……………………………………………………………………..205

David A. Lewis, Takanori Hashimoto, Jaime G. Maldonado-Aviles

and Harvey Morris

11. Increased Cortical Excitability as a Critical Element

in Schizophrenia Pathophysiology …………………………………………………………219

Patricio O’Donnell

Index………………………………………………………………………………………………………….237

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