The Serotonin Receptors



The serotonin receptors : from molecular pharmacology to human therapeutics / edited by

Bryan L. Roth,MD, PhD Department of Biochemistry Case Western Reserve University–School of Medicine

Cleveland, OH,2006 Humana Press Inc.

Comentario:

Contents:

ix

Preface………………………………………………………………………………………………… v

Contributors ……………………………………………………………………………………….. xi

Color Plate ………………………………………………………………………………………. xvii

1 Molecular Biology and Genomic Organization

of G Protein–Coupled Serotonin Receptors

Wesley K. Kroeze and Bryan L. Roth ……………………………………………. 1

2 Structure and Function Reveal Insights in the Pharmacology

of 5-HT Receptor Subtypes

Richard B. Westkaemper and Bryan L. Roth………………………………… 39

3 Polymorphic and Posttranscriptional Modifications of 5-HT

Receptor Structure: Functional and Pathological Implications

Marilyn A. Davies, Chiao-ying Chang, and Bryan L. Roth ……………. 59

4 Strategies for the Development of Selective Serotonergic Agents

Richard A. Glennon…………………………………………………………………… 91

5 5-HT Receptor Signal Transduction Pathways

John R. Raymond, Justin H. Turner, Andrew K. Gelasco,

Henry B. Ayiku, Sonya D. Coaxum, John M. Arthur,

and Maria N. Garnovskaya …………………………………………………143

6 Agonist-Directed Trafficking of 5-HT Receptor-Mediated Signal

Transduction

Kelly A. Berg and William P. Clarke …………………………………………207

7 Identification of 5-HT2 and 5-HT4 Receptor-Interacting

Proteins: A Proteomic Approach

Joël Bockaert, Carine Bécamel, Lara Joubert, Sophie Gavarini,

Aline Dumuis, and Philippe Marin ………………………………………237

x Contents

8 5-HT Receptor-Associated Proteins (FRAPs): Relevance for

Targeting, Trafficking, and Signal Transduction

Zongqi Xia, Douglas J. Sheffler, and Bryan L. Roth ……………………257

9 Cellular and Subcellular Localization of Serotonin Receptors

in the Central Nervous System

Laurent Descarries, Virginia Cornea-Hébert,

and Mustapha Riad …………………………………………………………….277

10 Chemical Neuroanatomy of 5-HT Receptor Subtypes in the

Mammalian Brain

Guadalupe Mengod, M. Teresa Vilaró, Roser Cortés,

Juan F. López-Giménez, Andreu Raurich,

and José M. Palacios ………………………………………………………….319

11 Modulation of the Neuronal Activity and Neurotransmitter

Release by 5-HT1A and 5-HT1B/1D Receptors

Pau Celada, Albert Adell, and Francesc Artigas …………………..365

12 Electrophysiology of 5-HT2A Receptors and Relevance for

Hallucinogen and Atypical Antipsychotic Drug Actions

Evelyn K. Lambe and George K. Aghajanian ……………………………..403

13 The Emergence of 5-HT2B Receptors as Targets to Avoid

in Designing and Refining Pharmaceuticals

Vincent Setola and Bryan L. Roth ……………………………………………..419

14 The 5-HT3 Receptor

Andrew J. Thompson, Li Zhang, and Sarah C. R. Lummis ……………439

15 5-HT3 and 5-HT4 Receptors as Targets for Drug Discovery

for Dementia

Frank Lezoualc’h and Magali Berthouze ……………………………………459

16 Electrophysiological Properties of Gαs-Coupled 5-HT

Receptors (5-HT4, 5-HT6, 5-HT7)

Rodrigo Andrade ……………………………………………………………………..481

17 5-HT6 Receptors as Targets for the Treatment of Cognitive

Deficits in Schizophrenia

Rudy Schreiber, Andrew Sleight, and Marie Woolley…………………..495

Contents xi

18 5-HT7 Receptors as Favorable Pharmacological Targets for

Drug Discovery

Peter B. Hedlund and J. Gregor Sutcliffe …………………………………..517

19 Serotonin System Gene Knockouts:

A Story of Mice With Implications for Man

Miles Berger and Laurence H. Tecott ………………………………………..537

20 Effects of Serotonin-Related Gene Deletion on Measures

of Anxiety, Depression, and Neurotransmission

Anita J. Bechtholt and Irwin Lucki …………………………………………….577

Index ……………………………………………………………………………………………….607

p. cm. — (The receptors)

Includes bibliographical references and index.

1. Serotonin—Receptors. 2. Serotonin—Physiological effect. 3. Serotoninergic mecha

nisms. I. Roth, Bryan L. II. Series.

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