GLUTAMATE AND ADDICTION
HUMANA PRESS TOTOWA, NEW JERSEY
Edited by
BARBARA H. HERMAN, PhD
Clinical Medical Branch, Division of Treatment Research and Development
National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH)
Bethesda, MD
Preface ......................................................................................................................... vii
Contributors.................................................................................................................. xv
I. INTRODUCTION: PHYSIOLOGY AND PHARMACOLOGY OF GLUTAMATE
Philip H. Sheridan, Forrest F. Weight, and Barbara H. Herman
Section Editors
1 Molecular Pharmacology and Physiology
of Glutamate Receptors ................................................................ 3
Karin Borges and Raymond Dingledine
2 Pharmacology of Glutamate Receptors .......................................... 23
Jeffrey M. Witkin, Rafal Kaminski,
and Michael A. Rogawski
3 Glutamate and Neurotoxicity.......................................................... 51
B. Joy Snider and Dennis W. Choi
4 Maturational Regulation of Glutamate Receptors
and Their Role in Neuroplasticity .............................................. 63
Russell M. Sanchez and Frances E. Jensen
5 Role of the NMDA Receptor in Neuronal Apoptosis
and HIV-Associated Dementia................................................... 71
Marcus Kaul and Stuart A. Lipton
II. GLUTAMATE: STIMULANT DRUGS OF ABUSE (COCAINE, AMPHETAMINE, METHAMPHETAMINE)
Jerry Frankenheim and Barbara H. Herman, Section Editors
6 Role of Glutamate and Nitric Oxide in the Acquisition
and Expression of Cocaine-Induced Conditioned
Increases in Locomotor Activity ................................................ 83
Agu Pert, Robert M. Post, and Susan R. B. Weiss
7 Interactions of Dopamine, Glutamate, and GABA Systems
in Mediating Amphetamine- and Cocaine-Induced
Stereotypy and Behavioral Sensitization ................................. 107
Ralph Karler, David K. Thai, and Larry D. Calder
8 Addiction and Glutamate-Dependent Plasticity ........................... 127
Marina E. Wolf
9 Glutamate and Dopamine Interactions in the Motive Circuit:
Implications for Craving ..........................................................143
David A. Baker, Jennifer L. Cornish, and Peter W. Kalivas
10 Glutamate Cascade from Metabotropic Glutamate Receptors
to Gene Expression in Striatal Neurons: Implications
for Psychostimulant Dependence and Medication .................. 157
John Q. Wang, Limin Mao, and Yuen-Sum Lau
Contents
11 Glutamate Neurotransmission in the Course of Cocaine
Addiction .................................................................................. 171
Luigi Pulvirenti
12 Glutamate and the Self-Administration of
Psychomotor-Stimulant Drugs ................................................. 183
Paul Vezina and Nobuyoshi Suto
13 Roles of Glutamate, Nitric Oxide, Oxidative Stress, and
Apoptosis in the Neurotoxicity of Methamphetamine ............ 201
Jean Lud Cadet
14 Methamphetamine Toxicity: Roles for Glutamate, Oxidative
Processes, and Metabolic Stress .............................................. 211
Kristan B. Burrows and Bryan K. Yamamoto
15 Nitric Oxide-Dependent Processes in the Action
of Psychostimulants .................................................................. 229
Yossef Itzhak, Julio L. Martin, and Syed F. Ali
16 Effects of Novel NMDA/Glycine-Site Antagonists
on the Blockade of Cocaine-Induced Behavioral
Toxicity in Mice ....................................................................... 243
Rae R. Matsumoto and Buddy Pouw
17 Clinical Studies Using NMDA Receptor Antagonists
in Cocaine and Opioid Dependence ......................................... 261
Adam Bisaga and Marian W. Fischman
18 The Role of mGluR5 in the Effects of Cocaine:
Implications for Medication Development .............................. 271
Mark P. Epping-Jordan
III. GLUTAMATE AND OPIATE DRUGS (HEROIN) OF ABUSE
Barbara H. Herman and Jerry Frankenheim, Section Editors
19 Role of the Glutamatergic System in Opioid Tolerance
and Dependence: Effects of NMDA Receptor Antagonists ...... 281
Jianren Mao
20 The Role of NMDA Receptors in Opiate Tolerance,
Sensitization, and Physical Dependence: A Review
of the Research, A Cellular Model, and Implications
for the Treatment of Pain and Addiction .................................295
Keith A. Trujillo
21 Modification of Conditioned Reward by
N-Methyl-D-aspartate Receptor Antagonists ........................... 323
Piotr Popik
22 Morphine Withdrawal as a State of Glutamate Hyperactivity:
The Effects of Glutamate Receptor Subtype Ligands
on Morphine Withdrawal Symptoms ........................................ 329
Kurt Rasmussen
IV. GLUTAMATE AND ALCOHOL ABUSE AND ALCOHOLISM
Forrest F. Weight and Raye Z. Litten, Section Editors
23 Alcohol Actions on Glutamate Receptors .................................... 343
Robert W. Peoples
24 Glutamate and Alcohol-Induced Neurotoxicity ........................... 357
Fulton T. Crews, Joseph G. Rudolph,
and L. Judson Chandler
25 Role of Glutamate in Alcohol Withdrawal Kindling ................... 375
Howard C. Becker and Nicole Redmond
26 Alcohol and Glutamate Neurotransmission in Humans:
Implications for Reward, Dependence, and Treatment ........... 389
John H. Krystal, Ismene L. Petrakis, D. Cyril D’Souza,
Graeme Mason, and Louis Trevisan
27 Mechanism of Action of Acamprosate Focusing
on the Glutamatergic System ................................................... 399
W. Zieglgänsberger, G. Rammes, R. Spanagel, W. Danysz,
and Ch. Parsons
28 The NMDA/Nitric Oxide Synthase Cascade in Opioid
Analgesia and Tolerance .......................................................... 409
Gavril W. Pasternak and Yuri Kolesnikov
29 Overview of Clinical Studies for Acamprosate ........................... 417
Adriaan S. Potgieter
Index ....................................... 427