Esquizofrenia Hoy.
Los Libros mas actuales en el tratamiento de la Esquizofrenia para descarga gratuita de los enfermos, los familiares y el personal medico.

Una Biblioteca Digital que crece cada día.

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Nuestra búsqueda de libros sobre la esquizofrenia y las enfermedades relacionadas ha sido infinitamente más rápida que nuestra capacidad para subir cada libro y comentarlo con detalle. Se nos han acumulado cientos de títulos y por ello hemos abierto esta Biblioteca Digital --Schizophrenia Digital Library—que reúne en un mismo lugar todos los enlaces de descarga como se van almacenando cada día.
Para hacer el acceso fácil al lector, basta buscar el enlace permanente en la parte derecha de esta página con la imagen que ahora ilustra este mensaje y hacer clic en la foto..
Ahí nuestros lectores podrán ir directo al listado donde están almacenados todos los enlaces y podrán descargar todos los libros que estén requiriendo.
El archivo crece cada día por lo que invitamos a compartir con nosotros este espacio de los dos siguientes modos:
1.- A nuestros lectores, (sean pacientes, familiares de un enfermo, médicos, estudiantes, o personas solidarias interesadas en apoyar el combate contra la Esquizofrenia), si tienen una página WEB personal o institucional, una página de Blog o un espacio en FaceBook, Twitter y redes similares; los invitamos a subir el enlace de Schizophrenia Digital Library con imagen y link para poder acceder de modo inmediato al archivo donde todo se almacena.
La idea es hacer lo mas fácil el acceso inmediato a las novedades en libros y noticias.
2.- Una vez que se ha ingresado al folder de Schizophrenia Digital Library, el lector puede suscribirse a un RSS, que es un servicio de aviso que envía información detallada de todo lo nuevo que se ha acumulado en la Biblioteca.
(Buscar el cuadrito anaranjado en la parte superior derecha. )

A quienes suban el enlace les suplicamos nos dejen un comentario con la dirección.
Al momento de hacer esta nota se han acumulado 343 libros. Los vamos a subir y comentar –en la medida de nuestra limitada capacidad—agrupándolos por tema. Así, esperamos entregar libros en paquetes como: Esquizofrenia y co- morbidez, avances en investigación genética, búsqueda de nuevos medicamentos, diccionarios y enciclopedias , etc.
Por favor dejen comentarios.
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Contemporary Directions in Psychopathology

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Contemporary Directions in Psychopathology: Scientific Foundations of the DSM-V and ICD-1 1, EDS: Theodore Millon PhD DSc, Robert F. Krueger PhD, Erik Simonsen MD
The Guilford Press | 2010 | ISBN: 160623532X | 622 pages | PDF | 4 MB


Un volumen que analiza y discute los mecanismos y sistemas usados para clasificar los desordenes mentales. Escrito y comentado por los expertos más destacados del ámbito internacional, entre los que se cuentan algunos directamente involucrados en la definición y desarrollo del DSM-V y el ICD-11 que son los documentos del estándar internacional para la clasificación de enfermedades mentales y desordenes de la personalidad.

This forward-thinking volume grapples with critical questions surrounding the mechanisms underlying mental disorders and the systems used for classifying them. Edited and written by leading international authorities, many of whom are actively involved with the development of DSM-V and ICD-11, the book integrates biological and psychosocial perspectives. It provides balanced analyses of such issues as the role of social context and culture in psychopathology and the pros and cons of categorical versus dimensional approaches to diagnosis. Cutting-edge diagnostic instruments and research methods are reviewed. Throughout, contributors highlight the implications of current theoretical and empirical advances for understanding real-world clinical problems and developing more effective treatments.

Contents

Part I. Historical and Cultural Perspectives

Chapter 1. A Précis of Psychopathological History 3

Theodore Millon and Erik Simonsen

Chapter 2. Themes in the Evolution of the 20th-Century DSM s 53

Roger K. Blashfield, Elizabeth Flanagan, and Kristin Raley

Chapter 3. On the Wisdom of Considering Culture and Context

in Psychopathology 72

Joseph P. Gone and Laurence J. Kirmayer

Chapter 4. Cultural Issues in the Coordination of DSM -V and ICD-11 97

Renato D. Alarcón

Chapter 5. A Sociocultural Conception of the Borderline

Personality Disorder Epidemic 111

Theodore Millon

Part II. Conceptual Issues in Classification

Chapter 6. Philosophical Issues in the Classification of Psychopathology 127

Peter Zachar and Kenneth S. Kendler

Chapter 7. Classification Considerations in Psychopathology and Personology 149

Chapter 8. Diagnostic Taxa as Open Concepts: Metatheoretical

and Statistical Questions about Reliability and Construct Validity

in the Grand Strategy of Nosological Revision 174

Paul E. Meehl

Chapter 9. Contemplations on Meehl (1986): The Territory, Paul’s Map,

and Our Progress in Psychopathology Classification

(or, the Challenge of Keeping Up with a Beacon 30 Years

Ahead of the Field) 187

Mark F. Lenzenweger

Chapter 10. Issues of Construct Validity in Psychological Diagnoses 205

Gregory T. Smith and Jessica Combs

Chapter 11. The Meaning of Comorbidity among Common Mental Disorders 223

Nicholas R. Eaton, Susan C. South, and Robert F. Krueger

Chapter 12. The Connections between Personality and Psychopathology 242

Susan C. South, Nicholas R. Eaton, and Robert F. Krueger

Chapter 13. Is It True That Mental Disorders Are So Common,

and So Commonly Co-Occur? 263

Mario Maj

Chapter 14. Taking Disorder Seriously: A Critique of Psychiatric Criteria

For Mental Disorders from the Harmful- function Perspective 275

Jerome C. Wakefield

Part III. Methodological App roaches to Categories, Dimensions,

And Prototypes

Chapter 15. On the Substantive Grounding and Clinical Utility of Categories

versus Dimensions 303

William M. Grove and Scott I. Vrieze

Chapter 16. A Short History of a Psychiatric Diagnostic Category

That Turned Out to Be a Disease 324

Roger K. Blashfield and Jared Keeley

Chapter 17. Concepts and Methods for Researching Categories

And Dimensions in Psychiatric Diagnosis 337

Helena Chmura Kraemer

Chapter 18. The Integration of Categorical and Dimensional Approaches

To Psychopathology 350

Erik Simonsen

Chapter 19. Dimensionalizing Existing Personality Disorder Categories 362

Andrew E. Skodol

Chapter 20. An Empirically Based Prototype Diagnostic System

for DSM -V and ICD-11 374

Kile M. Ortigo, Bekh Bradley, and Drew Westen

Chapter 21. The Millon Personality Spectrometer: A Tool for Personality

Spectrum Analyses, Diagnoses, and Treatments 391

Theodore Millon, Seth Grossman, and Robert Tringone

Part IV. Innovative Theoretical and Empi rical Proposals

Chapter 22. Neuroscientific Foundations of Psychopathology 419

Christopher J. Patrick and Edward M. Bernat

Chapter 23. Using Evolutionary Principles for Deducing Normal

and Abnormal Personality Patterns 453

Theodore Millon

Chapter 24. Biopsychosocial Models and Psychiatric Diagnosis 473

Joel Paris

Chapter 25. Reactivating the Psychodynamic Approach to the Classification

Of Psychopathology 483

Sidney J. Blatt and Patrick Luyten

Chapter 26. A Life Course Approach to Psychoses:

Outcome and Cultural Variation 515

Rina Dutta and Robin M. Murray

Chapter 27. The Interpersonal Nexus of Personality and Psychopathology 523

Aaron L. Pincus, Mark R. Lukowitsky, and Aidan G. C. Wright

Chapter 28. Reconceptualizing Autism Spectrum Disorders as Autism- S pecific

Learning Disabilities and Styles 553

Bryna Siegel

Chapter 29. Describing Relationship Patterns in DSM -V: A Preliminary Proposal 565

Marianne Z. Wamboldt, Steven R. H. Beach, Nadine Kaslow,

Richard Heyman, Michael First, and David Reiss

Chapter 30. On the Diversity of the Borderline Syndromes 577

Michael H. Stone

Author Index 595

Subject Index 607

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Schizophrenia in Children and Adolescents

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Schizophrenia in Children and Adolescents
Publisher: University | ISBN: 0521794285 | edition 2001 | PDF | 328 pages | 2,2 mb

Although schizophrenia is very difficult to diagnose in the young, early treatment is now thought to improve outcome. Recent research suggests that early onset schizophrenia has developmental precursors, making it difficult to distinguish from a number of other developmental disorders. In this timely book, an international team of psychiatrists, psychotherapists, and psychologists give an up-to-date review of the latest findings in the diagnosis andtreatment of schizophrenia in children and adolescents. It gives a comprehensive account of the current state of knowledge and the therapeutic options available to clinicians. The authors examine the disorder from developmental and clinical perspectives, focusing on diagnosis, etiology, therapy, and rehabilitation. This volume is essential reading for all mental health professionals who treat young people with schizophrenia.

Contents
List of contributors page xi
Preface xiii
1 Childhood psychosis and schizophrenia: a historical review 1
The late William Ll. Parry-Jones
Introduction 1
Historiography of schizophrenia 1
Psychotic juveniles in asylums 11
Premorbid characteristics and borderline disorder 12
Epidemiology 12
Theories of causation 13
Treatment and outcome 14
Conclusions 16
References 17
2 Definition and classification 24
Helmut Remschmidt
Introduction 24
Early descriptions 24
General criteria for the classification of psychotic disorders in children
and adolescents 26
Psychotic disorders in childhood and adolescence and their relation to
schizophrenia 28
The concept of positive and negative schizophrenia in children and
adolescents 30
Premorbid characteristics 32
Classification according to ICD-10 33
Classification according to DSM-IV 37
Conclusions 39
References 39
3 Epidemiology of early onset schizophrenia 43
Christopher Gillberg
Introduction 43
Childhood autism 44
Asperger syndrome 44
Disintegrative disorder and Rett syndrome variants 46
Landau–Kleffner syndrome and the syndrome of electrical status
epilepticus during sleep 46
Very early onset schizophrenia (12 years or under) 47
Adolescent onset schizophrenia (13–19 years of age) 51
Conclusions 54
References 54
4 Childhood schizophrenia: developmental aspects 60
Fred R. Volkmar
Introduction 60
Clinical features of childhood onset schizophrenia 63
Developmental issues in differential diagnosis 73
Summary and directions for further research 74
References 75
5 Diagnosis and differential diagnosis 82
Chris Hollis
Introduction 82
Historical background: an evolving diagnostic construct 84
Recent conceptual developments 86
Principles of clinical epidemiology: tools to estimate the usefulness of
diagnostic criteria 88
Diagnostic criteria: DSM-IV and ICD-10 91
Assessment: the pursuit of reliability 94
Diagnostic validity 97
Developmental variability: symptoms and associated features 100
The influence of age and cognition on symptom assessment 101
Are there continuities between premorbid developmental impairments
and psychotic symptoms? 103
Differential diagnosis 103
Is there continuity between the MDI syndrome and schizophrenia? 105
The differential diagnosis of psychotic symptoms in children and
adolescents 106
Differential diagnoses 107
Prevention and detection of ‘at risk’ or prodromal states 109
Conclusions 112
References 113
6 Genetic aspects 119
Jane ScourÞeldand Peter McGufÞn
Introduction 119
Defining the phenotype 119
Markers of vulnerability and childhood precursors 120
Genetic epidemiology 121
Type of inheritance 127
Molecular genetics 127
Conclusions 131
References 131
7 Neurobehavioral perspective 135
Robert F. Asarnow and Canan Karatekin
Introduction 135
Precursors of psychotic symptoms in schizophrenic children 136
Studies of cognitive/neuropsychological functioning 139
Link of cognitive impairment to formal thought disorder (FTD) and
discourse skills 151
Studies of event-related potentials (ERPs) 153
Neurobiology 156
Neurodevelopmental model 159
References 161
8 Psychosocial factors: the social context of child and adolescent onset
schizophrenia 168
Joan R. Asarnow, Martha C. Tompson and the late Michael J. Goldstein
Introduction 168
Schizophrenia in adolescence: psychosocial functioning and
developmental progressions 168
Follow-up studies 169
Premorbid adjustment and predictors of outcome 170
Family stress 171
Treatment strategies for schizophrenia in adolescents 173
The psychosocial treatment of adolescents with schizophrenia 181
Importance of early intervention 183
Conclusions 186
References 187
9 Treatment and rehabilitation 192
Helmut Remschmidt, Matthias Martin, Klaus Hennighausen and Eberhard Schulz
Neuroleptic (antipsychotic) agents and their properties 192
Electroconvulsive treatment (ECT) 228
Psychotherapeutic measures (see also Chapter 8) 232
Family oriented measures (see also Chapter 8) 240
Specific measures of rehabilitation 244
A comprehensive treatment and rehabilitation program 252
References 256
10 Course and prognosis 268
Sally Nicola Merry and John Scott Werry
Introduction 268
Selection of studies 272
Organization of the review 273
Premorbid adjustment 276
Onset 277
Course 280
Outcome 282
Factors affecting outcome 287
Summary and conclusions 293
References 294
Index 298

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The Gray Matter Series. (10 books on the Brain & its major functions

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Un paquete de 10 libros acerca de la estructura y funciones del cerebro humano y el sistema nervioso. Descarga gratuita.Free download.

Emotion and Stress (Gray Matter)
Chelsea House Publications | ISBN: 079109491X | 2007-04-30 | PDF | 128 pages | 6 Mb

Emotion is a universal language understood by all cultures. It is an integral part of our spoken and written language, our art, and our music. Various emotions enable us to respond quickly and appropriately to our environment. And stress, in turn, is created when environmental factors pose a potential threat to our safety. Our fast-paced world requires that we cope with stress in a manner that will harness its energy and minimize its potential to produce disease or distress. This book explains how negative emotions are often generated by stressful situations, and explores how both emotions and stress can have an impact on our health and well


Biofeedback (Gray Matter)
Chelsea House Publications | ISBN: 0791094367 | 2007-05-30 | PDF | 128 pages | 3 Mb

The human mind is a learning machine. We are constantly taking in new information, processing that information, and making decisions based on what we learn. Biofeedback is a process that teaches the mind so that it can learn to control the body. This book is a comprehensive look into this holistic type of learning; it explores how moods, muscles, nerves, and brain waves can be controlled by the mind through biofeedback treatment. "Biofeedback" also examines the discussions surrounding this topic. Though a lot of research has gone into exploring the mechanisms of biofeedback, science cannot explain exactly how the mind learns, so it cannot explain exactly how biofeedback works, either. And for this reason, biofeedback has long been questioned by traditional medicine.


Brain Facts (Gray Matter)
Chelsea House Publications | ISBN: 0791089568 | 2007-01-16 | PDF | 112 pages | 3 Mb

This offering from the Gray Matter series homes in on a number of topics related to the brain and how it functions. Topics presented in the 10 chapters include neurons, the senses, the autonomic nervous system, sleep, and language. Vera-Portocarrero cannot be accused of talking down to his audience. The terminology is more technical than in most books written for young people, and many high-school students will find themselves challenged by the difficult reading level and the dry writing style.



Cells of the Nervous System (Gray Matter)
Chelsea House Publications | ISBN: 0791085120 | 2005-09 | PDF | 147 pages | 3 Mb

Learn the difference between the two main types of cells in the nervous system: neurons and glial cells.


Sleep And Dreaming (Gray Matter)
Chelsea House Publications | ISBN: 0791086399 | 2005-09 | PDF | 159 pages | 3 Mb

The first title covers normal processes, such as REM sleep, as well as developmental disorders and other abnormalities, such as snoring, sleepwalking, and night terrors. Different perspectives about the meaning of dreams are also included, ranging from the theories of Freud and Jung to current research. Color photos, numerous sidebars, and a variety of quotations from history and literature are included. Spinal Cord is one of the few sources on this important topic for this audience. Subjects such as the role of the central nervous system and the functioning of spinal reflexes are discussed, along with abnormalities like pain and paralysis.


Sensation And Perception (Gray Matter)
Chelsea House Publications | ISBN: 0791089584 | 2007-06-30 | PDF | 128 pages | 3 Mb

Everything that we experience depends on sensing and perceiving. Specialized receptors for the five senses - hearing, seeing, smelling, tasting, and touching - capture information from chemical compounds, compressed air, electromagnetic waves, mechanical sensations, and more. From that information, our brain creates an impression of the world around us. "Sensation and Perception" focuses on how these systems work, from the mechanics of individual cells to the interactions of thousands of cells in the brain. This book also delves into how our sensory capabilities change with age or damage. Readers of this new title from the acclaimed "Gray Matter" series will learn to understand how sensation and perception prove crucial to interpreting our surroundings, enjoying them, and even surviving in them.


Learning And Memory (Gray Matter)
Chelsea House Publications | ISBN: 0791086380 | 2005-09 | PDF | 136 pages | 3 Mb

Grade 8 Up-These titles are excellent examples of extremely complex, abstract scientific topics made accessible to young readers. The first volume provides fascinating insights into various processes involved in how we learn different things in different ways. Particularly enlightening is the section differentiating explicit memory (learning facts) and implicit memory (learning processes). Midbrain stars the least flashy, less-well-researched part of the brain responsible for various movements (including Parkinson's problems), vision, hearing, sensuality, defense, and complex eye movements. The third volume traces the history of and controversies about manipulating consciousness.


Pain (Gray Matter)
Chelsea House Publications | ISBN: 0791089517 | 2007-01 | PDF | 128 pages | 5 Mb

Our bodies receive information about our internal state and the external environment through our sensory system. Touch, thermal, and pain stimuli, for example, are processed by this complex system. Specialized receptors detect stimuli and convert information into a neural code interpreted as sensation. The interpretation can be affected by the nervous system, as well as by surgery, medication, and the power of the mind. Pain explores the workings of the somatosensory and pain systems, how disorders can affect the way we process information, and how pain can be treated.


The Hindbrain (Gray Matter)
Chelsea House Publications | ISBN: 0791085104 | 2005-09 | PDF | 85 pages | 2 Mb

Learn about the section of the brain that oversees and regulates the function of the nervous system as a whole.


Speech And Language (Gray Matter)
Chelsea House Publications | ISBN: 0791089525 | 2006-12-30 | PDF | 112 pages | 3 Mb

This "Gray Matter" guide explores the ways we learn to speak and use language. The author reveals how and why children are able to develop language skills quickly, pinpoints the regions of the brain involved in coordinating speech and language, and describes various disorders that can disrupt language development. "Speech and Language" covers sign language and second languages, in addition to spoken language.







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Schizophrenia into Later Life: Treatment, Research, and Policy

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Schizophrenia into Later Life: Treatment, Research, and Policy
Publisher: American Psychiatric Publishing | ISBN: 1585620378 | edition 2003 | PDF | 344 pages | 1,39 mb

We are on the verge of a crisis in mental health. Over the next 30 years the number of chronically mentally ill people 55 years of age and older will double. With multiple disorders relating to mental illness and old age, these people will require unique services from a health care system that is ill prepared to deliver them. Schizophrenia Into Later Life: Treatment, Research, and Policy is the first major multidisciplinary reference on this important topicAa landmark work for researchers, service providers, and policy makers. Broad in scope, it discusses the demographic and clinical characteristics of older schizophrenic persons, details treatment approaches, suggests research strategies, and covers the relevant economic and health policy issues. -Unique. The most up-to-date, comprehensive source of information on this understudied group will help community psychiatrists, gerontologists, psychologists, policy makers, and social scientists meet a growing demand for services. -Multidisciplinary. Contributors have backgrounds in both aging and in biological psychiatry, social psychiatry, sociology, anthropology, social work, psychology, and neuropsychology to help professionals plan and deliver integrated services for the best outcome. -Comprehensive. Will serve as the key resource on the subject of schizophrenia in older people, covering epidemiology, biological aspects, psychosocial features, clinical care, and public policy. Today there is a distressing lack of age-appropriate clinical, rehabilitative, or residential programs for older patients with chronic mental illness. Schizophrenia in Later Life: Treatment, Research, and Policy will guide researchers, service providers, and policy makers in creating innovative new programs to help this underserved and growing population.


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Contents
Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix
Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xiii
Carl I. Cohen, M.D.
P•A•R•T I
Epidemiology, Historical Background,
Illness Phenomenology, and
Diagnostic Issues
C h a p t e r 1
Patterns of Care for Persons 65 Years and
Older With Schizophrenia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .3
Donna D. McAlpine, Ph.D.
C h a p t e r 2
Changes in Schizophrenia Across Time:
Paradoxes, Patterns, and Predictors. . . . . . . . . . . . . . . . . . . . . . . . . . . .19
Courtenay M. Harding, Ph.D.
C h a p t e r 3
A Comparison of Early- and Late-Onset Schizophrenia . . . . . . . . . . .43
Barton W. Palmer, Ph.D.
Gauri V. Nayak, M.A.
Dilip V. Jeste, M.D.
C h a p t e r 4
Differential Diagnosis of Psychotic Disorders in the Elderly . . . . . . .55
Abhilash K. Desai, M.D.
George T. Grossberg, M.D.

P•A•R•T II
Biological and
Medical Aspects
C h a p t e r 5
Biological Changes in Older Adults With Schizophrenia . . . . . . . . . .79
Susan K. Schultz, M.D.
C h a p t e r 6
Cognitive Functioning in Late-Life Schizophrenia:
Course and Correlates . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .93
Philip D. Harvey, Ph.D.
Joseph I. Friedman, M.D.
C h a p t e r 7
Medical Comorbidity in Older Persons With Schizophrenia . . . . . 113
Raymelle Schoos, M.D.
Carl I. Cohen, M.D.
P•A•R•T III
Gender and
Sociocultural Aspects
C h a p t e r 8
Gender Differences in Schizophrenia Across the Life Span . . . . . . 141
Mary V. Seeman, M.D.
C h a p t e r 9
Social Vicissitudes of Schizophrenia in Later Life . . . . . . . . . . . . . . 155
Carl I. Cohen, M.D.




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Identificada la desconexión cerebral de la esquizofrenia

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Identificada la desconexión cerebral de la esquizofrenia
Un experimento con ratones demuestra la alternación neuronal de base genética

EL PAÍS - Madrid - 02/04/2010 Unos ratones de laboratorio modificados genéticamente para que padezcan predisposición a la esquizofrenia han servido para demostrar cómo en esta enfermedad se interrumpen las conexiones entre la corteza prefrontal y el hipocampo. Además, los científicos han constatado que estos ratones tienen problemas de aprendizaje y memoria, un rasgo habitual de los pacientes con esquizofrenia. Investigaciones previas habían mostrado la alteración de estas conexiones neuronales en personas esquizofrénicas, pero sin aclarar si se trata de la causa o de la manifestación del problema. Para resolver la cuestión, un equipo de la Universidad de Columbia (EE UU) hizo unos ratones en los que modelizaron la mutación en el cromosoma 22 asociada a esta enfermedad en los humanos (aproximadamente el 30% de las personas que tienen esta mutación acaban padeciendo esquizofrenia). Un grupo de control de ratones normales permitió hacer las comparaciones en los experimentos y estudiar así el mecanismo cerebral específico que falla en esta patología. Los resultados de esta investigación se publican en la revista Nature. En los ratones normales, la sincronización neuronal se incrementa cuando memorizan algo, sin embargo, disminuye en los animales diseñados para ser esquizofrénicos. Joshua Gordon y sus colegas han comprobado que en los ratones normales el hipocampo envía información espacial a la corteza prefrontal, mientras que en los mutados se produce una interrupción de la conexión y esta comunicación falla. Para hacer los experimentos, los científicos utilizaron unas pruebas específicas para los ratones: tenían que orientarse en un laberinto y, para salir airosos, debían memorizar la dirección en que se desplazaban y dirigirse al lado opuesto para recibir su recompensa. Los animales normales aprendían pronto, pero los otros tardaban más, lo que muestra un déficit en la ejecución de la tarea. "Descubrimos que para cumplir con éxito el ejercicio, nuestros ratones sanos necesitaban que actuasen conjuntamente las dos partes del cerebro -el hipocampo y la corteza prefrontal-, pero en los ratones modelo, la transferencia de información era menos eficaz o no se producía en absoluto", explica Gordon. El experimento, al relacionar directamente la mutación del cromosoma 22 con esta conectividad cerebral y la memoria y el aprendizaje, aclara la influencia de los genes en este rasgo de la esquizofrenia. Los estudios previos realizados en humanos, aunque habían correlacionado la base genética con los problemas de la sincronización neuronal, no habían aclarado el mecanismo subyacente, e incluso dejaban abierta la posibilidad de que los fallos de la conectividad cerebral se debieran a la medicación utilizada por los pacientes. En el experimento con ratones "estamos realmente al nivel de las neuronas individuales, así que nuestros hallazgos se extienden más allá de los estudios de pacientes, mostrando cómo la conectividad cerebral afectada puede emerger al nivel de una neurona debido a una variación genética de riesgo", explica Torfi Sigurdsson. La esquizofrenia es una enfermedad cerebral crónica y grave que afecta a poco más del 1% de la población adulta y se caracteriza por pérdida de contacto con la realidad, alucinaciones, pensamiento alterado, aislamiento social y disminución de la motivación, explica un comunicado de la Universidad de Columbia. Suele manifestarse en adultos jóvenes. © EDICIONES EL PAÍS S.L. - Miguel Yuste 40 - 28037 Madrid [España] - Tel. 91 337 8200 .

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Principles and Practice of Psychopharmacotherapy

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Principles & Practice of Psychopharmacotherapy, 4th Edition/

Authors: Janicak, Philip G.; Davis, John M.; Preskorn, Sheldon H.; Ayd, Frank J.; Marder, Stephen R.; Pavuluri, Mani N.

2006 Lippincott Williams & Wilkins.

Comentario:

Contents:

Chapter 1 – General Principles

Chapter 2 – Pharmacodynamics and Pharmacokinetics

Chapter 3 – Assessment of Drug Efficacy and Relevant Clinical Issues

Chapter 4 – Indications for Antipsychotics

Chapter 5 – Treatment with Antipsychotics

Chapter 6 – Indications for Antidepressants

Chapter 7 – Treatment with Antidepressants

Chapter 8 – Treatment with Electroconvulsive Therapy and Other Device-Based Therapies

Chapter 9 – Indications for Mood Stabilizers

Chapter 10 – Treatment with Mood Stabilizers

Chapter 11 – Indications for Antianxiety and Sedative-Hypnotic Agents

Chapter 12 – Treatment with Antianxiety and Sedative-Hypnotic Agents

Chapter 13 – Assessment and Treatment of Anxiety-Related Disorders

Chapter 14 – Psychopharmacotherapy in Early Life

Chapter 15 – Psychopharmacotherapy in Later Life

Chapter 16 – Psychopharmacotherapy in Special Populations



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Principles & Practice of Psychopharmacotherapy.PDF



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Preclinical Drug Development

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Preclinical drug development/edited by Mark C. Rogge, David R. Taft.
2nd ed. 2010 by Informa Healthcare USA, Inc.

Comentario:
Contents:
Preface . . . . vii
Contributors . . . . xi
1. The Scope of Preclinical Drug Development: An Introduction and Framework 1
Mark C. Rogge
2. Lead Molecule Selection: Pharmaceutical Profiling and Toxicity Assessments 7
P. L. Bullock
3. Interspecies Differences in Physiology and Pharmacology: Extrapolating Preclinical
Data to Human Populations 35
M. N. Martinez
4. Pharmacokinetics/ADME of Small Molecules 71
A. D. Ajavon and David R. Taft
5. Pharmacokinetics/ADME of Large Molecules 117
R. Braeckman
6. Preclinical Pharmacokinetic–Pharmacodynamic Modeling and Simulation in Drug
Development 142
P. L. Bonate and P. Vicini
7. Formulation and Production Strategies for Enhancing Bioavailability of Poorly
Absorbed Drugs 161
A. B. Watts and R. O. Williams III
8. Transporters Involved in Drug Disposition, Toxicity, and Efficacy 196
C. Q. Xia and G. T. Miwa
9. Toxicity Evaluations, ICH Guidelines, and Current Practice 231
J. L. Larson
10. Application of Pathology in Safety Assessment 271
Robert A. Ettlin and David E. Prentice
11. Utilizing the Preclinical Database to Support Clinical Drug Development 336
H. Lee
Index . . . . 349
Preclinical drug development/edited by Mark C. Rogge, David R. Taft.—2nd ed.
(Drugs and the pharmaceutical sciences; 187)
1. Drug development. I. Rogge, Mark C.

II. Taft, David R. III. Series: Drugs and the pharmaceutical sciences; v. 187.
[DNLM: 1. Drug Evaluation, Preclinical – methods. 2. Drug Industry – methods.


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Pharmacogenomics in Drug Discovery and Development

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Pharmacogenomics in Drug Discovery and Development/Edited by Qing Yan, PharmTao
Santa Clara, CA, USA 2008 Humana Press

Comentario:

Contents:
ix
Chapter 1 The Integration of Personalized and Systems Medicine:
Bioinformatics Support for Pharmacogenomics
and Drug Discovery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Qing Yan
Chapter 2 Applications of Microarrays and Biochips
in Pharmacogenomics. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21
Gary Hardiman
Chapter 3 Confounding in Genetic Association Studies
and Its Solutions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31
Donglei Hu and Elad Ziv
Chapter 4 Pharmacogenetics of Membrane Transporters: A Review
of Current Approaches . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41
Tristan M. Sissung, Erin R. Gardner, Rui Gao,
and William D. Figg
Chapter 5 Pharmacogenomics of Drug-Metabolizing
Enzymes and Drug Transporters in Chemotherapy . . . . . . . . 63
Tessa M. Bosch
Chapter 6 Pharmacogenomics of G Protein-Coupled Receptor
Signaling: Insights from Health and Disease . . . . . . . . . . . . . . 77
Miles D. Thompson, David E. C. Cole, and Pedro A. Jose
Chapter 7 G Protein-Coupled Receptors Disrupted in Human
Genetic Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109
Miles D. Thompson, Maire E. Percy, W. McIntyre Burnham,
and David E. C. Cole
Chapter 8 G Protein-Coupled Receptor Pharmacogenetics . . . . . . . . . . 139
Miles D. Thompson, Katherine A. Siminoivitch,
and David E. C. Cole
Chapter 9 Epigenetic Alterations of the Dopaminergic System
in Major Psychiatric Disorders . . . . . . . . . . . . . . . . . . . . . . . . 187
Hamid Mostafavi Abdolmaleky, Cassandra L. Smith,
Jin-Rong Zhou, and Sam Thiagalingam
Chapter 10 Pharmacogenomics in Alzheimer’s Disease . . . . . . . . . . . . . . 213
Ramón Cacabelos
Chapter 11 Pharmacogenetics of Asthma. . . . . . . . . . . . . . . . . . . . . . . . . . 359
Gregory A. Hawkins and Stephen P. Peters
Chapter 12 From SNPs to Functional Studies in Cardiovascular
Pharmacogenomics. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 379
Sharon Cresci
Chapter 13 Pharmacogenomics in Gastrointestinal Disorders . . . . . . . . 395
Michael Camilleri and Yuri A. Saito
Chapter 14 Pharmacogenomics in Rheumatoid Arthritis . . . . . . . . . . . . 413
Prabha Ranganathan
Chapter 15 Cancer Pharmacogenetics . . . . . . . . . . . . . . . . . . . . . . . . . . . . 437
Sharon Marsh
Chapter 16 Pharmacogenomics in the Preclinical Development
of Vaccines: Evaluation of Efficacy and Systemic
Toxicity in the Mouse Using Array Technology. . . . . . . . . . . . 447
Karin J. Regnström
Chapter 17 Pharmacogenomics in the Evaluation of Efficacy
and Adverse Events During Clinical Development
of Vaccines. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 469
Lennart J. Nilsson and Karin J. Regnström
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 481

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Molecular Neuropharmacology, Strategies and Methods-Humana

15:49
MOLECULAR NEUROPHARMACOLOGY Strategies and Methods/ edited by Arne Schousboe and Hans Bräuner-Osborne.2004 Humana Press Inc.

Comentartio:

CONTENTS:

Preface ………………………………………………………………………………………………………………………………. v

Contributors …………………………………………………………………………………………………………………….. ix

Color Plates ……………………………………………………………………………………………………………………… xi

PART I. MOLECULAR PHARMACOLOGY OF GLUTAMATE RECEPTORS

1 Computational Studies of Ligand–Receptor Interactions

in Ionotropic Glutamate Receptors ……………………………………………………………………… 3

Jeremy R. Greenwood and Tommy Liljefors

2 Delineation of the Physiological Role of Kainate Receptors

by Use of Subtype Selective Ligands …………………………………………………………………. 27

Sari E. Lauri, Vernon R. J. Clarke, and Graham L. Collingridge

3 Molecular Pharmacology of the Metabotropic Glutamate Receptors ……………………. 47

Anders A. Jensen

PART II. MOLECULAR PHARMACOLOGY OF GABA RECEPTORS

4 Functional Characterization of GABAA Receptor Ligands In Vitro:

Correlation With In Vivo Activity…………………………………………………………………………. 85

Bjarke Ebert, Sally Anne Thompson, Signe Í Stórustovu, and Keith A. Wafford

5 In Vivo Function of GABAA Receptor Subtypes Unraveled

With Mutant Mice ……………………………………………………………………………………………… 95

Jean-Marc Fritschy

6 Characterization of the GABAA Receptor Recognition Site

Through Ligand Design and Pharmacophore Modeling ………………………………… 113

Bente Frølund, Anne T. Jørgensen, Tommy Liljefors, Martin Mortensen,

and Povl Krogsgaard-Larsen

7 The GABAB Receptor: From Cloning to Knockout Mice ………………………………………….. 129

Bernhard Bettler and Hans Bräuner-Osborne

PART III. MOLECULAR PHARMACOLOGY

OF TRANSMITTER TRANSPORTERS

8 Structure and Molecular Characterization of the Substrate-Binding Sites

of the Dual-Function Glutamate Transporters ………………………………………………… 147

Baruch I. Kanner, Michael P. Kavanaugh, and Lars Borre

9 Allosteric Modulation of Glutamate Transporters ………………………………………………. 161

Robert J. Vandenberg and Renae M. Ryan

10 Characterization of the Substrate-Binding Site in GABA Transporters ………………. 175

Alan Sarup, Orla Miller Larsson, and Arne Schousboe

11 Insights From Endogenous and Engineered Zn2 Binding Sites

in Monoamine Transporters …………………………………………………………………………….. 191

Claus Juul Loland and Ulrik Gether

12 A Structural Context for Studying Neurotransmitter

Transporter Function ……………………………………………………………………………………….. 213

Naomi R. Goldberg, Thijs Beuming, Harel Weinstein,

and Jonathan A. Javitch

13 Functional Mechanisms of G Protein-Coupled Receptors

in a Structural Context …………………………………………………………………………………….. 235

Marta Filizola, Irache Visiers, Lucy Skrabanek, Fabien Campagne,

and Harel Weinstein

Index ……………………………………………………………………………………………………………………………… 267

1. Neurotransmitter receptors. 2. Neuropharmacology. 3. Molecular pharmacology. I. Schousboe, Arne. II.

Bräuner-Osborne, Hans.

[DNLM: 1. Neuopharmacology--methods. 2. Receptors, Neurotransmitter. 3. Neurotransmitters. 4. Receptors, GABA. 5.

Receptors, Glutamate.


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