Comentartio:

CONTENTS:

Preface ………………………………………………………………………………………………………………………………. v

Contributors …………………………………………………………………………………………………………………….. ix

Color Plates ……………………………………………………………………………………………………………………… xi

PART I. MOLECULAR PHARMACOLOGY OF GLUTAMATE RECEPTORS

1 Computational Studies of Ligand–Receptor Interactions

in Ionotropic Glutamate Receptors ……………………………………………………………………… 3

Jeremy R. Greenwood and Tommy Liljefors

2 Delineation of the Physiological Role of Kainate Receptors

by Use of Subtype Selective Ligands …………………………………………………………………. 27

Sari E. Lauri, Vernon R. J. Clarke, and Graham L. Collingridge

3 Molecular Pharmacology of the Metabotropic Glutamate Receptors ……………………. 47

Anders A. Jensen

PART II. MOLECULAR PHARMACOLOGY OF GABA RECEPTORS

4 Functional Characterization of GABAA Receptor Ligands In Vitro:

Correlation With In Vivo Activity…………………………………………………………………………. 85

Bjarke Ebert, Sally Anne Thompson, Signe Í Stórustovu, and Keith A. Wafford

5 In Vivo Function of GABAA Receptor Subtypes Unraveled

With Mutant Mice ……………………………………………………………………………………………… 95

Jean-Marc Fritschy

6 Characterization of the GABAA Receptor Recognition Site

Through Ligand Design and Pharmacophore Modeling ………………………………… 113

Bente Frølund, Anne T. Jørgensen, Tommy Liljefors, Martin Mortensen,

and Povl Krogsgaard-Larsen

7 The GABAB Receptor: From Cloning to Knockout Mice ………………………………………….. 129

Bernhard Bettler and Hans Bräuner-Osborne

PART III. MOLECULAR PHARMACOLOGY

OF TRANSMITTER TRANSPORTERS

8 Structure and Molecular Characterization of the Substrate-Binding Sites

of the Dual-Function Glutamate Transporters ………………………………………………… 147

Baruch I. Kanner, Michael P. Kavanaugh, and Lars Borre

9 Allosteric Modulation of Glutamate Transporters ………………………………………………. 161

Robert J. Vandenberg and Renae M. Ryan

10 Characterization of the Substrate-Binding Site in GABA Transporters ………………. 175

Alan Sarup, Orla Miller Larsson, and Arne Schousboe

11 Insights From Endogenous and Engineered Zn2 Binding Sites

in Monoamine Transporters …………………………………………………………………………….. 191

Claus Juul Loland and Ulrik Gether

12 A Structural Context for Studying Neurotransmitter

Transporter Function ……………………………………………………………………………………….. 213

Naomi R. Goldberg, Thijs Beuming, Harel Weinstein,

and Jonathan A. Javitch

13 Functional Mechanisms of G Protein-Coupled Receptors

in a Structural Context …………………………………………………………………………………….. 235

Marta Filizola, Irache Visiers, Lucy Skrabanek, Fabien Campagne,

and Harel Weinstein

Index ……………………………………………………………………………………………………………………………… 267

1. Neurotransmitter receptors. 2. Neuropharmacology. 3. Molecular pharmacology. I. Schousboe, Arne. II.

Bräuner-Osborne, Hans.

[DNLM: 1. Neuopharmacology--methods. 2. Receptors, Neurotransmitter. 3. Neurotransmitters. 4. Receptors, GABA. 5.

Receptors, Glutamate.

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