The Glutamate Receptors
Edited by
Robert W. Gereau, IV, PhD
Washington University Pain Center, Department of Anesthesiology
and Department of Anatomy and Neurobiology, Washington University
School of Medicine, St. Louis, MO
and
Geoffrey T. Swanson, PhD
Department of Molecular Pharmacology and Biological Chemistry,
Northwestern University Feinberg School of Medicine, Chicago, IL
Edited by
Robert W. Gereau, IV, PhD
Washington University Pain Center, Department of Anesthesiology
and Department of Anatomy and Neurobiology, Washington University
School of Medicine, St. Louis, MO
and
Geoffrey T. Swanson, PhD
Department of Molecular Pharmacology and Biological Chemistry,
Northwestern University Feinberg School of Medicine, Chicago, IL
Contents
Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v
Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix
1. AMPA Receptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Michael C. Ashby, Michael I. Daw, and John T. R. Isaac
2. NMDA Receptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45
Ronald S. Petralia and Robert J. Wenthold
3. Kainate Receptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99
Anis Contractor and Geoffrey T. Swanson
4. Delta Receptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 159
Michisuke Yuzaki
5. Ionotropic Glutamate Receptors in Synaptic Plasticity . . . . . . . . 179
Kenneth A. Pelkey and Chris J. McBain
6. Structural Correlates of Ionotropic Glutamate Receptor
Function . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 247
Anders S. Kristensen, Kasper B. Hansen, Lonnie P. Wollmuth,
Jan Egebjerg, and Stephen F. Traynelis
7. Positive Modulators of AMPA-Type Glutamate Receptors:
Progress and Prospects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 299
Gary Lynch and Christine M. Gall
8. Clinically Tolerated Strategies for NMDA Receptor
Antagonism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 327
Huei-Sheng Vincent Chen, Dongxian Zhang, and Stuart A. Lipton
9. The Structures of Metabotropic Glutamate Receptors . . . . . . . . . 363
David R. Hampson, Erin M. Rose, and Jordan E. Antflick
10. Group I Metabotropic Glutamate Receptors
(mGlu1 and mGlu5) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 387
Julie Anne Saugstad and Susan Lynn Ingram
vii
viii Contents
11. Group II Metabotropic Glutamate Receptors
(mGlu2 and mGlu3) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 465
Michael P. Johnson and Darryle D. Schoepp
12. Group III Metabotropic Glutamate Receptors
(mGlu4, mGlu6, mGlu7, and mGlu8) . . . . . . . . . . . . . . . . . . . 489
Volker Neugebauer
13. Metabotropic Glutamate Receptor-Dependent
Synaptic Plasticity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 509
Stephen M. Fitzjohn and Zafar I. Bashir
14. Metabotropic Glutamate Receptor Ligands as Novel
Therapeutic Agents . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 529
Ashley E. Brady and P. Jeffrey Conn
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 565
Publicar un comentario