Contents
Foreword ..........................................................................V...........
Preface ...............................................................................VII.........
Contributors ......................................................................XIII..........
Color Plates ........................................................................XXI........
Neuropeptides and Behavior
Evolution of Neuropeptide Concepts Illustrated by MIF-1 and
MSH
W. Pan and A.J. Kastin .......................................................3
Increased Leptin Supply to Hypothalamus by Gene Therapy
Confers Life-Long Benefits on Energy Homeostasis, Disease
Cluster of Metabolic Syndrome--Diabetes Type 1 and 2,
Dyslipidemia and Cardiovascular Ailments--and Bone
Remodeling
S.P. Kalra .............................................................................19
Feeding Regulation in the Brain: Involvement of Neuropeptide W
E Takenoya, H. Kageyama, Y. Date, M. Nakazato,
and S. Shioda ......................................................................31.
Feeding Regulation in the Brain: Role of Galanin-Like Peptide
(GALP)
H. Kageyama, E Takenoya, and S. Shioda .......................41.

Neuropeptides, Bioamines, and Clinical Implications
Neuropeptide Y and Its Role in Anxiety-Related Disorders
Y. Dumont, J.C. Morales-Medina, and R. Quirion .............51
The Search for a Fetal Origin for Autism: Evidence of
Aberrant Brain Development in a Rat Model of Autism
Produced by Prenatal Exposure to Valproate
T. Ogawa, M. Kuwagata, and S. Shioda ............................83


X Contents
Sexually Dimorphism and Social Brain Circuit: Its Implication
to Autism
H. Yamasue and N. Kato ..................................................... 89
Functional Mapping of Sensory and Motor
Brain Activity
Stimulating Music: Combining Melodic Intonation Therapy
with Transcranial DC Stimulation to Facilitate Speech
Recovery After Stroke
B.W. Vines, A.C. Norton, and G. Schlaug .........................103
Serotonin Release Acts on 5-HT2 Receptors in the
Dorsomedial Medulla Oblongata to Elicit Airway Dilation in
Mice
M. Kanamaru and I. Homma .............................................115.
Breathing Is to Live, to Smell and to Feel
Y. Masaoka and I. Homma .................................................125
Role of the Medial Frontal Wall for Readiness of Motor
Execution
M. Inoue, Y. Masaoka, M. Kawamura, Y. Okamoto,
and I. Homma .....................................................................137.
Poster Presentations
Ryanodine Receptor Type 1 / Calcium Release Channel in the
Endoplasmic Reticulum as the Target of Nitric Oxide to Cause
the Intracellular Calcium Signaling
H. Oyamada, T. Yamazawa, T. Murayama, T. Hayashi,
T. Sakurai, M. Iino, and K. Oguchi ....................................155
Decreased Sensitivity to Negative Facial Emotions
and Limbic Lesions in Patients with Myotonic Dystrophy
Type 1
M. Kawamura, A. Takeda, M. Kobayakawa, A. Suzuki,
M. Kondo, and N. Tsuruya .................................................161
Contents XI
Generation of Rac 1 Conditional Mutant Mice by Cre/loxP
System
D. Suzuki, A. Yamada, T. Amano, A. Kimura,
R. Yasuhara, M. Sakahara, M. Tamura, N. Tsumaki,
S. Takeda, M. Nakamura, T. Shiroishi, A. Aiba,
and R. Kamijo .....................................................................175
Orexin Modulates Neuronal Activities of Mesencephalic
Trigeminal Sensory Neurons in Rats
K. Nakayama, A. Mochizuki, S. Nakamura,
T. Inoue ..............................................................................179..
Investigation of the Anxiolytic Effects of Kampo Formulation,
Kamishoyosan, Used for Treating Menopausal Psychotic
Syndromes in Women
K. Toriizuka, Y. Hori, M. Fukumura, S. Isoda, Y. Hirai,
and Y. Ida ............................................................................183.
Activation of Microglia Induced Learning and Memory
Deficits
S. Tanaka, H. Ohtaki, T. Nakamachi, S. Numazawa,
S. Shioda, and T. Yoshida ...................................................191
Increased Behavioral Activity with Regular Circadian Rhythm
in PACAP Specific Receptor (PAC1) Transgenic Mice
S. Arata, T. Hosono, Y. Taketomi, H. Kageyama,
T. Nakamachi, and S. Shioda ............................................199..
Expression and Localization of Pituitary Adenylate
Cyclase-Activating Polypeptide (PACAP) Specific Receptor
(PAC1R) After Traumatic Brain Injury in Mice
K. Morikawa, K. Dohi, S. Yofu, Y. Mihara,
T. Nakamachi, H. Ohtaki, S. Shioda, and T. Aruga ...........207
Key Word Index ................................................................ 211....